I have a standing PubMed search on Guanfacine because it's a long used medication that was recently found to be an "alpha 2A adrenoceptor". That's making it the subject of extensive research, such as:
- changes in neuronal connectivity
- extended release works well in children and adolescents
- strengthening working memory networks (?)
- better prefrontal cortical regulation of behavior in aging animals (?)
The challenge is that this medication will be taken for a very long time by very large numbers of children, often in combination with Ritalin. There are sure to be surprises, both good and bad. We don't know it nearly as well as we do Ritalin.